Modulation of macrophage response mechanisms against persistent pathogens by PUFA
نویسنده
چکیده
Infectious diseases occur when a pathogen overwhelms a host`s immune response, establishes a local niche, replicates and spreads over the whole body. Immunocompromised people are especially in danger to develop severe pathologies. An important factor influencing the immune defence is the diet. In particular polyunsaturated fatty acids (PUFA) are believed to play a key role in modulating immune response mechanisms. The present review intends to summarise actual data concerning the immune modulation by PUFA thereby focussing on macrophage defence mechanisms. This includes the impact of PUFA on macrophage membrane composition, macrophage phagocytosis, macrophage respiratory burst as well as macrophage cytokine synthesis.
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